Leishmaniasis is a parasitic disease that kills hundreds of thousands annually, recently a compound to combat it has been isolated, called Norjuliol. We tested a possible synthesis pathway to create Norjuliol like compounds, for future Norjuliol synthesis and anti-leishmaniasis testing. The products of the different synthesis steps were characterized using proton NMR (400 MHz). The results show the hydrazone and boronic acid synthesis pathway should not be used for Norjuliol. Previous research has shown that the synthesis with methoxy groups on the boronic acid is possible, but the data collected demonstrated the reaction difficult with multiple methoxy groups. The initial testing of Norjuliol like compounds with alcohol groups against leishmaniasis has shown promise and have shown better results than the current treatment. Further testing is needed for definitive conclusions to be drawn.
